rigid registration is achieved by minimization of the sum of squared intensity differences (SSD) between two images.
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The INRIAlign toolbox enhances the standard SPM realignment routine (see topic: spm_realign_ui in SPM99 documentation). In the latter, rigid registration is achieved by minimization of the sum of squared intensity differences (SSD) between two images. As noted by several SPM users, SSD based registration may be biased by a variety of image artifacts and also by activated areas. To get around this problem, INRIAlign reduces the influence of large intensity differences by weighting errors using a non-quadratic, slowly-increasing function (rho function). This is basically the principle of an M-estimator.